HER3 and mutant EGFR meet MET

Article Abstract:

Studies conducted reveal that non-small-cell lung caners with activating mutations in the epidermal growth factor receptor (EGFR) develop resistance to tyrosine kinase inhibitors by recruiting the MET receptor kinase to activate HER3 and the P13K-Akt cell survival pathway.

Health aspects, Lung cancer, Non-small cell, Non-small cell lung cancer, Epidermal growth factor receptors

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An important difference

Article Abstract:

The discovery of mutations in the genome of tumour cells when transferred into other cells caused transformation is studied. It confirms that concept of the cellular oncogene by the cloning of cellular RAS, and the activating mutation is identified.

Cancer cells, Cell transformation

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Poring over pores: [alpha]-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia

Article Abstract:

The contribution of [beta]-channel pore-forming toxins ([beta]-CFTs) to the pathogenesis of lung infections is discusses with clinically relevant community-associated, methicillin-resistant strains (CA-MRSA) strains LAC (USA300) and MW2 (USA400).

Pneumonia, Staphylococcus, Bacterial pneumonia, Staphylococcus aureus infections

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